Medical plastic packaging film USES very wide, not only can be used for tablet, powder, granule pharmaceutical packaging, can also be used for lining paper carton packing paste, liquid, and drugs and medical devices such as packaging, film shrink film, wrapping film, multilayer composite membrane, etc. In pharmaceutical packaging, the use of glass bottles, plastic bottles are gradually replaced by a plastic film, especially the medicinal liquid plastic flexible packaging, such as infusion bag, plasma bag development more quickly.
According to the industrial market research company Freedonia Grouplnc. According to the survey, in 1997 ~ 2007 global pharmaceuticals packaging demand an average annual growth rate of 4.3% (see chart 1). According to the market intelligence organization according to the study of the pharmaceutical packaging market, in the packaging market $3.246 billion total sales of traditional Chinese medicine packaging film, bags accounted for 28%. The annual worth of Utah's pharmaceutical packaging industry in our country is in 15 billion yuan, an average annual growth rate of more than 10%. In recent years, the proportion of the application of plastics in our country medical packaging is rapidly improving. Data show that China's drug tablet with aluminum, plastic packing ratio has risen from 10% in 1990 to 40% now, medical plastic film has become hot spot film new development. Is expected in 2005 China's pharmaceutical tablet, capsule, with plastic packaging demand will increase to 4 billion. There are many kinds of medical plastic film, are widely used are mainly PE, PP, PET, PEN (polyethylene naphthalate formic acid glycol ester) PA, PVA, PVC, PVDC, PC, and the new development of cycloolefin copolymers (COC), etc., the dosage of polyolefin is the largest. Raw material to the diversified development 1, PE According to Mastio company on the market survey report shows that PE film, PE medical plastic packaging film of plastic film, is one of the fastest growing varieties. It is predicted that the next few years the global medical PE plastic film demand will be growing at an average annual rate of 7%. Medical PE film is the biggest potential growth market infection prevention medical supplies bags, followed by a one-time lining membrane, small packaging and medical apparatus and instruments for wrapping film. At present there are more than 40 companies around the world producing medical PE packaging products, the top five is Clopay company (Griffon Corp), P1iant company, Maxxin medical supplies company, Rexam medical packaging company and Banta care, their market share of about 50%. Medical PE film, the dosage is the fastest growing LLDPE, the dosage of the LLDPE medical film market in 2003 medical PE film, 52% of the total consumption is expected to reach 54% in 2006. LLDPE is the major cause of the rapid development of medical film because it can be obtained under the same thickness strength higher than that of LDPE film, thin film can be obtained from thereby, save raw materials, reduce the cost. LDPE medical film in recent years the annual output of more than 40000 t, accounting for 39% of the total amount, second. HDPE, MDPE dosage is small, the market share below 10%. 2, PP metallocene catalytic vinyl plastic body and PP blend can improve PP film after radiation embrittlement resistance, can be used in the packaging of medical devices. In recent years, through the modification of PP, its development in the medicinal liquid packaging has made great progress. Buxter company after screening for raw materials, think if use medicinal liquid flexible packaging bags, PP production needs comprehensive isotactic PP high melting point and the flexibility of the flexible PP block structure, the two kinds of materials have excellent softness and flexible, good low temperature toughness and higher than the melting point of 121 oc, at the same time because its density is about 30% less than PVC, so that the unit cost close to PVC. MontellCatalloy copolymer is reported to the company and the huntsman, the company's flexible polyolefin FPOs meet the above requirements, is currently in the United States and Asia produced Rxloy products, has obtained the production license in Europe. But FPOs crystallinity is relatively low, the crystallinity of PP 99% 99% ~ 17%, and has a certain viscosity, difficult to handle, so often need through blending to improve its performance, such as Adflexks353 must be used, the density of 0.89 g/cm3 material as the surface layer, to ensure the strength and the melting point of more than 121 oc, surface need to use the special resin of high level of transparency for transparency. Also by co-extrusion technology can get rid of disadvantages of PP surface fog degrees, through the formulation design can improve PP heat sealing performance, using density is 0.89 g/cm3 brand of PP resin, thickness can be thinned, cost reduction, etc. Amoco and Stanford university jointly developed the performance of PVC PP elastomer which is similar. Exxon and the dow chemical company development mLLDPE are testing in the medicinal liquid flexible packaging bags, they have excellent cleanliness, transparency and mechanical properties, but also can decrease the thickness of the thin film has the potential of cost advantage. But mLLDPE melting point is lower, can not adapt to under 121 oc to disinfection treatment for 20 min, so it is mainly used for the body excrete fluid collection bags, if used for infusion bag, blood transfusion bag still needs further modification. In polyolefin as alternative material of PVC, development process, as a result of medical products in disinfection sterilization, filling, sealing, such as the use process requires the use of special polyolefin resin, so the high cost become one of the important reasons for the polyolefin cannot quickly instead of PVC. However, by changing processing conditions and use of new additives, PP performance are being gradually improved in recent years, in addition heat sealing and sterilization condition and other problems associated with the assembly line, can be addressed by equipment improvement. Therefore, PP film can be used for the fourth generation of infusion bag and plasma bag is just around the corner. 3, PVC PVC with good chemical resistance, mechanical properties and electric properties, but poor resistance to heat and light stability. PVC film can be used in a rolling process, extrusion blow molding method may be adopted in production. Because of PVC resin for heat sensitive and the hardness is big, so soft, thin film processing must add heat stabilizer and plasticizer and its soft and semi-rigid film can be widely used in medical use infusion bag and blood transfusion bag, when used in medical packaging material, vinyl chloride monomer content in PVC resin should be less than LMG  , you should use non-toxic heat stabilizer and plasticizer migration, non-toxic, not easily to ensure the safety of the product. Rigid PVC film can be used as a drug packaging film, mostly transparent or amber film, after vacuum forming small concave nest filled tablets, then coated with EVA cover material composite heat sealing agent. In order to improve the thermal resistance, and cover material PVC lining is coated EVA or PVDC coatings.In recent years due to the PVC flexible packaging use of phthalic acid esters plasticizer is considered toxic and PVC flexible packaging bags after use is not easy to recycling of environmental problems, has led to a serious use in Concorde challenges, especially in some European countries PVC pharmaceutical packaging market is gradually shrinking. 4, PA PA film has strong toughness and good durability thorn resistance, durability, chemical resistance, its temperature range is wide, but the hygroscopicity, poor heat sealing and made so many and polyolefin composite film is used. Because a good PA film comprehensive performance is very suitable for protection during shipping has good medical instrument disinfection, so medical equipment packing will be PA film new applications. 5, CTEF film CTFE film is made of three fluorine ethylene inyl chloride copolymer, high transparency, flame retardant, the permeability resistance; Good. The film has a unique range of application, below 195.50 C is still soft, its melting point at 182 ~ 204 oc. 6, PET Two-way stretch of PET film has high mechanical strength and rigidity, high heat resistance, resistance is good, very good transparency and gloss, moisture and oxygen permeability is lesser, have very good taste and non-toxic. PET film can be directly used in contact with the drug, often used for packing tablets especially Chinese medicine pills. Also because of its high heat-resistance and protect flavor, can be used as a layer in the multi-layer composite membrane resistance, to ensure that the tablets in the period of validity is not bad.
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